Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters

ByPFAS Primer Team

Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. With a sample size of 197 firefighters, the report quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. November 2, 2021 | Future…

Identification of point source dischargers of per- and polyfluoroalkyl substances in the United States

ByPFAS Primer Team

The report provides a screening-level analysis of the potential for environmental PFAS releases from contaminated sites, active industrial sites, wastewater treatment plants, and waste disposal sites (including active and inactive landfills) nationwide. November 2, 2021 | American Water Works Association Water Science

Concentration profiles of per- and polyfluoroalkyl substances in major sources to the environment

ByPFAS Primer Team

A review of published literature was conducted to present the concentrations and composition profiles of per- and polyfluoroalkyl substances (PFAS) from significant sources to the environment. The characteristic compounds and concentrations are summarized as found from direct sources such as manufacturing facilities, aqueous film-forming foam (AFFF) applications, metal coating operations, and textile and paper coating…

Information Requirements under the Essential-Use Concept: PFAS Case Studies

ByPFAS Primer Team

This study investigates how much information is available on the types and functions of PFAS in these uses, how much information is available on alternatives to the use of PFAS in various products, their performance and hazardous properties and, finally, whether this information is sufficient as a basis for deciding on the essentiality of a…

The Dilemma of perfluorooctanoate (PFOA) human half-life

ByPFAS Primer Team

Based on information from both human observational studies and clinical data, this study proposed a range for the half-life for PFOA of 0.5 to 1.5 years, which would likely raise many existing regulatory safe levels if all other parameters stayed the same. August 25, 2021 | Regulatory Toxicology and Pharmacology